Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Autor(es)

Carlin, V. ^[1] ; Artioli, A. J. ^[2] ; Matsumoto, M. A. ^[2] ; Filho, H. N. ; Borgo, E. ^[3] ; Oshima, C. T. F. ^[1] ; Ribeiro, D. A. ^{[4, 1]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Paulista Med Sch, Dept Pathol, BR-11060001 Santos, SP - Brazil

^[2] Sagrado Coracao Univ, Discipline Oral & Maxillofacial Surg, Dept Hlth Sci, Sao Paulo - Brazil

^[3] PI Branemark Inst, Bauru, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Dentomaxillofacial Radiology; v. 39, n. 5, p. 295-299, JUL 2010.
• Citações Web of Science: 15

Resumo

Objectives: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure. Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included. Results: No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. In contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05). Conclusion: In summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 295-299. doi: 10.1259/dmfr/17573156 (AU)

• Processo FAPESP: 07/01228-4 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
• Beneficiário: Daniel Araki Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 07/00345-7 - Danos no DNA promovidos por íons metálicos provenientes de aparelhos ortodônticos fixos: análises in vitro e in vivo
• Beneficiário: Daniel Araki Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular