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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

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Author(s):
Carlin, V. [1] ; Artioli, A. J. [2] ; Matsumoto, M. A. [2] ; Filho, H. N. ; Borgo, E. [3] ; Oshima, C. T. F. [1] ; Ribeiro, D. A. [4, 1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Paulista Med Sch, Dept Pathol, BR-11060001 Santos, SP - Brazil
[2] Sagrado Coracao Univ, Discipline Oral & Maxillofacial Surg, Dept Hlth Sci, Sao Paulo - Brazil
[3] PI Branemark Inst, Bauru, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Dentomaxillofacial Radiology; v. 39, n. 5, p. 295-299, JUL 2010.
Web of Science Citations: 15
Abstract

Objectives: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure. Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included. Results: No significant statistically differences (P > 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. In contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P < 0.05). Conclusion: In summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 295-299. doi: 10.1259/dmfr/17573156 (AU)

FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Daniel Araki Ribeiro
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 07/00345-7 - DNA damage induced by metal ions from orthodontic therapy: in vivo and in vitro analyses
Grantee:Daniel Araki Ribeiro
Support Opportunities: Regular Research Grants