Birth weight and bone mass in young adults from Brazil

Autor(es)

Schlussel, Michael Maia ^[1] ; Sisson de Castro, Jose Augusto ^[2] ; Kac, Gilberto ^{[1, 3]} ; Moura da Silva, Antonio Augusto ^[4] ; Cardoso, Viviane Cunha ^[5] ; Bettiol, Heloisa ^[5] ; Barbieri, Marco Antonio ^[5]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio de Janeiro, Inst Nutr Josue Castro, Grad Program Nutr, Rio De Janeiro - Brazil

^[2] Univ Fed Rio Grande do Sul, Sch Med, Dept Internal Med, Porto Alegre, RS - Brazil

^[3] Univ Fed Rio de Janeiro, Inst Nutr Josue Castro, Dept Social & Appl Nutr, Rio De Janeiro - Brazil

^[4] Univ Fed Maranhao, Dept Publ Hlth, Sao Luis, MA - Brazil

^[5] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Puericulture & Pediat, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BONE; v. 46, n. 4, p. 957-963, APR 2010.
• Citações Web of Science: 8

Resumo

Background: Birth weight is positively associated with adult bone mass. However, it is not clear if its effect is already evident in early adulthood. Objective: To investigate the association between birth weight, adult body size, the interaction between them and bone mass in young adults. Methods: Bone densitometry by DXA was performed on 496 individuals (240 men) aged 23-24 years from the 1978/79 Ribeirao Preto (southern Brazil) birth cohort, who were born and still residing in the city in 2002. Birth weight and length as well as adult weight and height were directly measured and converted to z-scores. The influence of birth weight and length, and adult weight and height on bone area (BA), bone mineral content (BMC) and bone mineral density (BMD) at the lumbar spine, proximal femur and femoral neck were investigated through simple and multiple linear regression models. Adjustments were made for sex, skin color, gestational age, physical activity level, smoking status and dietary consumption of protein, calcium and alcohol. Interaction terms between birth weight and adult weight, and birth length and adult height were tested. Results: Men in the highest fertile of birth weight distribution had greater BA and BMC at all three bone sites when compared with their counterparts in the lowest tertiles (p<0.008). For BMD, this trend was observed only in the lumbar spine. Adult weight and height were positively associated with BA and BMC at all three bone sites (p<0.05). For BMD, these associations were seen for adult weight, but for adult height an association was observed only in the lumbar spine. Birth weight retained positive associations with proximal femur BA and BMC after adjustments for current weight and height. No interaction was observed between variables measuring prenatal growth and adult body size. Conclusion: Birth weight and postnatal growth are independent determinants of adult bone mass in a sample of Brazilian adults. This effect is already evident in early adulthood. (C) 2010 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 00/09508-7 - Da saúde perinatal à saúde do adulto jovem: estudo da coorte nascida em 1978/79 nos hospitais de Ribeirão Preto, SP
• Beneficiário: Marco Antonio Barbieri
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 97/09517-1 - Estudo epidemiológico-social longitudinal da saúde da criança de uma coorte em 3 momentos: ao nascer, na idade escolar e aos 18 anos
• Beneficiário: Marco Antonio Barbieri
• Modalidade de apoio: Auxílio à Pesquisa - Regular