Occurrence of AFM(1) in urine samples of a Brazilian population and association with food consumption

Autor(es)

Romero, Alessandra de Cassia ^[1] ; Baroni Ferreira, Tania Raquel ^[1] ; dos Santos Dias, Carlos Tadeu ^[2] ; Calori-Domingues, Maria Antonia ^[1] ; da Gloria, Eduardo Micotti ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Agroind Food & Nutr, ESALQ, BR-13418900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Exact Sci, ESALQ, BR-13418900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FOOD CONTROL; v. 21, n. 4, p. 554-558, APR 2010.
• Citações Web of Science: 36

Resumo

This survey evaluated the presence of AFM(1) in human urine samples from a specific Brazilian population, as well as corn, peanut, and milk consumption measured by two types of food inquiry. Urine samples from donors who live in the city of Piracicaba, State of Sao Paulo, Brazil were analyzed to detect the presence of aflatoxin M(1) (AFM(1)). an aflatoxin B(1) metabolite, which may be used as aflatoxin B(1) exposure biomarker. The AFM(1) analysis was performed using immunoaffinity clean-up and detection by high-performance-liquid chromatography with fluorescence detector. A total of 69 samples were analyzed and 45 of them (65%) presented contaminations >= 1.8 pg ml(-1), which was the limit of quantification (LOQ). Seventy eight percent (n = 54) of the samples presented detectable concentrations of AFM(1) (>0.6 pg ml(-1)). The AFM(1) concentration among samples above LOQ ranged from 1.8 to 39.9 pg ml(-1). There were differences in food consumption profile among donors, although no association was found between food consumption and AFM(1) concentration in urine. The high frequency of positive samples suggests exposure of the populations studied to aflatoxins. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 05/53308-6 - Mensuração de biomarcador da exposição às aflatoxinas em fluidos humanos
• Beneficiário: Alessandra de Cássia Romero
• Modalidade de apoio: Bolsas no Brasil - Mestrado