Role of the CYP2D6, EPHX1, MPO, and NQO1 Genes in the Susceptibility to Acute Lymphoblastic Leukemia in Brazilian Children

Autor(es)

Silveira, Vanessa da Silva ^[1] ; Canalle, Renata ^[2] ; Scrideli, Carlos Alberto ^[3] ; de Paula Queiroz, Rosane Gomes ^[3] ; Tone, Luiz Gonzaga ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Piaui, Colegiado Biomed, Parnaiba, Piaui - Brazil

^[3] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Environmental and Molecular Mutagenesis; v. 51, n. 1, p. 48-56, JAN 2010.
• Citações Web of Science: 27

Resumo

Polymorphic variations of several genes associated with dietary effects and exposure to environmental carcinogens may influence susceptibility to leukemia development. The objective of the present study was to evaluate the effect of the polymorphisms of debrisoquine hydroxylase (CYP2D6), epoxide hydrolase (EPHX1), myeloperoxidase (MPO), and quinone-oxoreductase (NQO1), which have been implicated in xenobiotic metabolism, on the risk of childhood acute lymphoblastic leukemia (ALL). We evaluated the frequency of polymorphisms in the CYP2D6 ({*}3 and {*}4), EPHX1 ({*}2 and {*}3), MPO ({*}2), and NQO1 ({*}2) genes in 206 patients with childhood ALL and in 364 healthy individuals matched for age and gender from a Brazilian population separated by ethnicity (European ancestry and African ancestry), using the PCR-RFLP method. The CYP2D6 polymorphism variants were associated with an increased risk of ALL. The EPHX1, NQO1, and MPO variant genotypes were significantly associated with a reduced risk of childhood ALL. A significantly stronger protective effect is observed when the EPHX1, NQO1, and MPO variant genotypes are combined suggesting that, CYP2D6 polymorphisms may play a role in the susceptibility to pediatric ALL, whereas the EPHX1, NQO1, and MPO polymorphisms might have a protective function against leukemogenesis. Environ. Mal. Mulagen. 51:48-56, 2010. (C) 2009 Wiley-Liss, Inc. (AU)

• Processo FAPESP: 03/02527-4 - Polimorfismos genéticos, suscetibilidade e resposta ao tratamento em crianças portadoras de leucemia linfoblástica aguda
• Beneficiário: Luiz Gonzaga Tone
• Modalidade de apoio: Auxílio à Pesquisa - Regular