Pharmacokinetic profile of liposome-encapsulated ropivacaine after maxillary infiltration anaesthesia

Autor(es)

Franz-Montan, Michelle ^[1] ; Bergamaschi, Cristiane de Cassia ^[1] ; de Paula, Eneida ^[2] ; Groppo, Francisco C. ^[1] ; Ranali, Jose ^[1] ; Fraceto, Leonardo Fernandes ^[3] ; Volpato, Maria C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP - Brazil

^[3] Julio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 21, n. 10, p. 1945-1951, 2010.
• Citações Web of Science: 4

Resumo

The aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received maxillary infiltration of liposome-encapsulated 0.5% ropivacaine and, 0.5% ropivacaine with 1:200,000 epinephrine in two different sessions. Blood samples were collected before and after (from 15 to 1440 min) the administration of either ropivacaine formulation. HPLC with UV detection was used to quantify plasma ropivacaine concentrations. The pharmacokinetic parameters AUC0-24 (area under the plasma concentration × time curve from baseline to 24 h), AUC0-∞ (area under the plasma concentration-time curve from baseline to infinity), Cmax (maximum drug concentration), CL (renal clearance), Tmax (maximum drug concentration time), t1/2 (elimination half-life) and Vd (volume of distribution) were analyzed using the Wilcoxon signed-rank test. No differences (p > 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. Both formulations showed similar pharmacokinetic profiles, indicating that the liposomal formulation could be a safer option for use of this local anesthetic, due to the absence of a vasoconstrictor. (AU)

• Processo FAPESP: 06/53255-2 - Avaliacao da eficacia anestesica da ropivacaina encapsulada ou nao em lipossomas, em anestesia odontologica.
• Beneficiário: Michelle Franz Montan Braga Leite
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 06/00121-9 - Novas formulações de anestésicos locais de liberação controlada: do desenvolvimento ao teste clínico odontológico
• Beneficiário: Eneida de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Temático