Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

Autor(es)

Alvarenga, Tathiana A. ^[1] ; Andersen, Monica L. ^[1] ; Ribeiro, Daniel A. ; Araujo, Paula ^[1] ; Hirotsu, Camila ^[1] ; Costa, Jose L. ; Battisti, Murilo C. ^[1] ; Tufik, Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ADDICTION BIOLOGY; v. 15, n. 1, p. 96-99, JAN 2010.
• Citações Web of Science: 29

Resumo

We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins. (AU)

• Processo FAPESP: 09/01030-5 - Efeito da privação e restrição de sono na função reprodutiva de ratos machos
• Beneficiário: Tathiana Aparecida Fernandes de Alvarenga
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 07/01228-4 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
• Beneficiário: Daniel Araki Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs