Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

Author(s)

Alvarenga, Tathiana A. ^[1] ; Andersen, Monica L. ^[1] ; Ribeiro, Daniel A. ; Araujo, Paula ^[1] ; Hirotsu, Camila ^[1] ; Costa, Jose L. ; Battisti, Murilo C. ^[1] ; Tufik, Sergio ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: ADDICTION BIOLOGY; v. 15, n. 1, p. 96-99, JAN 2010.
• Web of Science Citations: 29

Abstract

We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins. (AU)

• FAPESP's process: 09/01030-5 - Effect of sleep deprivation and sleep restriction on the reproductive function of male rats
• Grantee: Tathiana Aparecida Fernandes de Alvarenga
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
• Grantee: Daniel Araki Ribeiro
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC