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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

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Author(s):
Alvarenga, Tathiana A. [1] ; Andersen, Monica L. [1] ; Ribeiro, Daniel A. ; Araujo, Paula [1] ; Hirotsu, Camila [1] ; Costa, Jose L. ; Battisti, Murilo C. [1] ; Tufik, Sergio [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ADDICTION BIOLOGY; v. 15, n. 1, p. 96-99, JAN 2010.
Web of Science Citations: 30
Abstract

We evaluated the overall genetic damage induced by different doses of cocaine and MDMA (3,4-Methylenedioxymethamphetamine) in several organs. One hour after intraperitoneal drug administration, mice were euthanized; peripheral blood, liver and brain were collected, and the cellular suspensions were used for the single cell gel (comet) assay. We determined that all doses of cocaine and MDMA tested were able to induce DNA damage in blood cells. Extensive genotoxic damage was induced by cocaine or MDMA at the highest doses used in liver cells. Brain cells were affected by all doses administrated. These findings demonstrate that cocaine and MDMA are potent genotoxins. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Daniel Araki Ribeiro
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 09/01030-5 - Effect of sleep deprivation and sleep restriction on the reproductive function of male rats
Grantee:Tathiana Aparecida Fernandes de Alvarenga
Support type: Scholarships in Brazil - Doctorate