Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

Autor(es)

Bellomo, Ana ^[1] ; Bertucci, Ana ^[2] ; Stefani, Helio ^{[3, 4]} ; Vazquez, Alvaro ^[2] ; Gonzalez, David ^[1]

Afiliação do(s) autor(es)

^[1] Univ Republica, UdelaR, Fac Quim, Lab Sintesis Organ, Montevideo - Uruguay

^[2] Univ Republica, UdelaR, Fac Quim, Lab Farmacognosia & Prod Nat, Montevideo - Uruguay

^[3] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TETRAHEDRON-ASYMMETRY; v. 20, n. 23, p. 2673-2676, DEC 11 2009.
• Citações Web of Science: 10

Resumo

The first synthesis of two selenyldeoxycyclitols (4-bromo-2-phenylselenyl conduritol F and 6-phenylselenylconduritol F) is reported via a chemoenzymatic enantioselective route. The key step of the synthesis is the selenolysis of a vinyl epoxide. The new compounds were evaluated for their capacity to inhibit the growth of different microorganisms using a modification of the agar diffusion technique with thin layer chromatography plates as support. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 07/59404-2 - Reações entre sais de potássio de organotrifluoroboratos e espécies eletrofílicas de telúrio e haletos orgânicos
• Beneficiário: Helio Alexandre Stefani
• Modalidade de apoio: Auxílio à Pesquisa - Temático