Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

Full text
Author(s):
Bellomo, Ana [1] ; Bertucci, Ana [2] ; Stefani, Helio [3, 4] ; Vazquez, Alvaro [2] ; Gonzalez, David [1]
Total Authors: 5
Affiliation:
[1] Univ Republica, UdelaR, Fac Quim, Lab Sintesis Organ, Montevideo - Uruguay
[2] Univ Republica, UdelaR, Fac Quim, Lab Farmacognosia & Prod Nat, Montevideo - Uruguay
[3] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: TETRAHEDRON-ASYMMETRY; v. 20, n. 23, p. 2673-2676, DEC 11 2009.
Web of Science Citations: 10
Abstract

The first synthesis of two selenyldeoxycyclitols (4-bromo-2-phenylselenyl conduritol F and 6-phenylselenylconduritol F) is reported via a chemoenzymatic enantioselective route. The key step of the synthesis is the selenolysis of a vinyl epoxide. The new compounds were evaluated for their capacity to inhibit the growth of different microorganisms using a modification of the agar diffusion technique with thin layer chromatography plates as support. (C) 2009 Elsevier Ltd. All rights reserved. (AU)