In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae)

Autor(es)

da Silva Filho, A. A. ^[1] ; Resende, D. O. ^[1] ; Fukui, M. J. ^[1] ; Santos, F. F. ^[1] ; Pauletti, P. M. ^[1] ; Cunha, W. R. ^[1] ; Silva, M. L. A. ^[1] ; Gregorio, L. E. ^[2] ; Bastos, J. K. ^[2] ; Nanayakkara, N. P. D. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Franca, Lab Prod Nat, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 - USA

• Tipo de documento: Artigo Científico
• Fonte: Fitoterapia; v. 80, n. 8, p. 478-482, DEC 2009.
• Citações Web of Science: 63

Resumo

Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani. with an IC(50) value of 45 mu g/mL. while GPE presented an IC(50) value of 49 mu g/mL Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 mu g/mL and 7.0 mu g/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 mu g/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 mu g/mL (D6 clone). (C) 2009 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/60132-4 - Investigação das atividades esquistossomicida, tripanocida e leishmanicida de lignanas e neolignanas obtidas por acoplamento oxidativo in vitro de fenilpropanóides
• Beneficiário: Ademar Alves da Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores