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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae)

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Author(s):
da Silva Filho, A. A. [1] ; Resende, D. O. [1] ; Fukui, M. J. [1] ; Santos, F. F. [1] ; Pauletti, P. M. [1] ; Cunha, W. R. [1] ; Silva, M. L. A. [1] ; Gregorio, L. E. [2] ; Bastos, J. K. [2] ; Nanayakkara, N. P. D. [3]
Total Authors: 10
Affiliation:
[1] Univ Franca, Lab Prod Nat, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 - USA
Total Affiliations: 3
Document type: Journal article
Source: Fitoterapia; v. 80, n. 8, p. 478-482, DEC 2009.
Web of Science Citations: 63
Abstract

Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani. with an IC(50) value of 45 mu g/mL. while GPE presented an IC(50) value of 49 mu g/mL Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 mu g/mL and 7.0 mu g/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 mu g/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 mu g/mL (D6 clone). (C) 2009 Elsevier B.V. All rights reserved. (AU)