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Baccharis L. (Asteraceae) and endophytic fungi: secondary metabolites and biological activities

Grant number: 14/21593-2
Support type:Regular Research Grants
Duration: October 01, 2015 - December 31, 2017
Field of knowledge:Biological Sciences - Botany
Principal Investigator:Marcelo José Pena Ferreira
Grantee:Marcelo José Pena Ferreira
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Asteraceae is one the world's largest families of Eudicots comprising several species used for economic and medicinal purposes, characterized by the production of important bioactive metabolites. However, few studies have regarded the chemical and biological diversity of the microorganisms associated with the species native from highland fields. The aim of this project is to explore the metabolome of non-studied Baccharis species, and their associated endophytic fungi, as a source of new bioactive compounds. After the isolation of endophytic fungi, the crude extracts from plants and fungal species will be prepared, fractionated and subjected to bioassays (antifungal, antiradical, anti-inflammatory, antiviral, antitumoral, antileishmanial and allelopathic activities). The identification of compounds will be carried out through the dereplication methods. Bioactive samples will be purified and the new compounds identified and assessed in biological assays. The project also aims to assess whether there is an influence of reproductive phenology on the diversity of endophytic fungi in dioecious species of Baccharis. In addition to establishing a new line of research in the Department of Botany (IB-USP) covering studies with endophytic microorganisms, this interdisciplinary project will contribute to the expansion of knowledge about the chemical diversity and biological potential of Baccharis species and endophytic fungi from Brazil. (AU)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZAMPIERI, PAULO R. F.; TAMAYOSE, CINTHIA I.; FAVERO, ORIANA A.; ROMOFF, PAULETE; FERREIRA, MARCELO J. P. Two New Flavonoids from the Leaves of Baccharis oblongifolia (Ruiz and Pav.) Pers. (Asteraceae). Molecules, v. 24, n. 17 SEP 1 2019. Web of Science Citations: 0.
BITTENCOURT RODRIGUES, CAROLINE FABRI; PENA FERREIRA, MARCELO JOSE; BELCHOR, MARIANA NOVO; COSTA, CAROLINE R. C.; NOVAES, DANIELLE P.; DOS SANTOS JUNIOR, ADEILSO BISPO; TAMAYOSE, CINTHIA I.; TERASHIMA PINHO, MARCUS VINICIUS; DE OLIVEIRA, MARCOS ANTONIO; TOYAMA, MARCOS HIKARI. Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2. MARINE DRUGS, v. 17, n. 7 JUL 2019. Web of Science Citations: 0.
INDY TAMAYOSE, CINTHIA; DOS SANTOS, EVELYNE A.; ROQUE, NADIA; COSTA-LOTUFO, LETICIA V.; PENA FERREIRA, MARCELO J. Caffeoylquinic Acids: Separation Method, Antiradical Properties and Cytotoxicity. CHEMISTRY & BIODIVERSITY, v. 16, n. 7 JUL 2019. Web of Science Citations: 1.
TAMAYOSE, C. I.; TORRES, P. B.; ROQUE, N.; FERREIRA, M. J. P. HIV-1 reverse transcriptase inhibitory activity of flavones and chlorogenic acid derivatives from Moquiniastrum floribundum (Asteraceae). SOUTH AFRICAN JOURNAL OF BOTANY, v. 123, p. 142-146, JUL 2019. Web of Science Citations: 2.
UENO, ANDERSON K.; BARCELLOS, ALINE F.; GRECCO, SIMONE DOS S.; SARTORELLI, PATRICIA; GUADAGNIN, RAFAEL C.; ROMOFF, PAULETE; FERREIRA, MARCELO JOSE P.; TCACENCO, CELIZE M.; LAGO, JOAO HENRIQUE G. Sesquiterpenes, diterpenes, alkenyl p-coumarates, and flavonoid from the aerial parts of Baccharis retusa (Asteraceae). Biochemical Systematics and Ecology, v. 78, p. 39-42, JUN 2018. Web of Science Citations: 1.

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