Comparative evaluation of the erbB2 and hormone receptor status of neighboring invasive and in situ components of ductal carcinomas of the breast

Autor(es):Mostrar menos -

Rodrigues Peres, Raquel Mary ^[1] ; Serra, Katia Piton ^[2] ; Derchain, Sophie F. M. ^[2] ; Yoon, Jung Hyun ; Pinto, Glauce Aparecida ^[1] ; Alvarenga, Marcelo ^[2] ; Soares, Fernando Augusto ^[3] ; Heinrich, Juliana K. ^[1] ; da Cunha, Isabela Werneck ^[3] ; Vassallo, Jose ; Sarian, Luis Otavio ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, CAISM, Womens Hosp, BR-13083881 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Dept Obstet & Gynecol, BR-13083881 Campinas, SP - Brazil

^[3] Hosp Canc AC Camargo, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Markers; v. 24, n. 4, p. 238-244, OCT-DEC 2009.
• Citações Web of Science: 1

Resumo

Background: It remains unknown whether erbB2 expression and hormone receptor status predict the invasive potential of ductal carcinoma in situ (DCIS) of the breast. Objectives: To examine erbB2 and estrogen/progesterone receptor (ER/PR) status in the precise areas where DCIS turns into invasive ductal carcinoma (IDC). Subjects and methods: Eighty-seven cases of breast malignancies harboring contiguous regions of DCIS and IDC were selected. Separate histological samples from the DCIS and the neighboring IDC were obtained using tissue microarrays. The erbB2 and ER/PR statuses were assessed using immunohistochemistry (erbB2 and ER/PR) and fluorescence in situ hybridization (FISH only erbB2). Results: The expression of erbB2 did not differ in the DCIS and IDC components of the breast tumors (p=0.35). There was good agreement in sample-by-sample comparisons of erbB2 (intraclass correlation coefficient {[}ICC]=0.78), PR (ICC=0.61) and ER (ICC=0.70) expression in the DCIS and IDC components. Conclusion: Our findings suggest that the expressions of erbB2 and ER/PR do not differ in the contiguous regions from DCIS to IDC. (Int J Biol Markers 2009; 24: 238-44) (AU)

• Processo FAPESP: 08/02469-8 - Instabilidade genômica em neoplasias malignas da mama em função da presença do receptor de estrógeno e da concentração de alumínio intracelular
• Beneficiário: Luís Otávio Zanatta Sarian
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/08536-9 - Expressão da COX-2 em carcinomas de mama invasor e in situ e sua relação com a expressão de HER2, mutação p53 e receptores de estrógeno e de progesterona
• Beneficiário: Sophie Françoise Mauricette Derchain
• Modalidade de apoio: Auxílio à Pesquisa - Regular