Comparative evaluation of the erbB2 and hormone receptor status of neighboring invasive and in situ components of ductal carcinomas of the breast

Author(s):Show less -

Rodrigues Peres, Raquel Mary ^[1] ; Serra, Katia Piton ^[2] ; Derchain, Sophie F. M. ^[2] ; Yoon, Jung Hyun ; Pinto, Glauce Aparecida ^[1] ; Alvarenga, Marcelo ^[2] ; Soares, Fernando Augusto ^[3] ; Heinrich, Juliana K. ^[1] ; da Cunha, Isabela Werneck ^[3] ; Vassallo, Jose ; Sarian, Luis Otavio ^[2]

Affiliation

^[1] Univ Estadual Campinas, CAISM, Womens Hosp, BR-13083881 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Dept Obstet & Gynecol, BR-13083881 Campinas, SP - Brazil

^[3] Hosp Canc AC Camargo, Sao Paulo - Brazil

• Document type: Journal article
• Source: International Journal of Biological Markers; v. 24, n. 4, p. 238-244, OCT-DEC 2009.
• Web of Science Citations: 1

Abstract

Background: It remains unknown whether erbB2 expression and hormone receptor status predict the invasive potential of ductal carcinoma in situ (DCIS) of the breast. Objectives: To examine erbB2 and estrogen/progesterone receptor (ER/PR) status in the precise areas where DCIS turns into invasive ductal carcinoma (IDC). Subjects and methods: Eighty-seven cases of breast malignancies harboring contiguous regions of DCIS and IDC were selected. Separate histological samples from the DCIS and the neighboring IDC were obtained using tissue microarrays. The erbB2 and ER/PR statuses were assessed using immunohistochemistry (erbB2 and ER/PR) and fluorescence in situ hybridization (FISH only erbB2). Results: The expression of erbB2 did not differ in the DCIS and IDC components of the breast tumors (p=0.35). There was good agreement in sample-by-sample comparisons of erbB2 (intraclass correlation coefficient {[}ICC]=0.78), PR (ICC=0.61) and ER (ICC=0.70) expression in the DCIS and IDC components. Conclusion: Our findings suggest that the expressions of erbB2 and ER/PR do not differ in the contiguous regions from DCIS to IDC. (Int J Biol Markers 2009; 24: 238-44) (AU)

• FAPESP's process: 08/02469-8 - Genomic instability in breast malignant tumors as related to the concentration of intracelular aluminium and to estrogen receptor status
• Grantee: Luís Otávio Zanatta Sarian
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/08536-9 - Expression of COX-2 in invasive and in situ breast carcinoma and its relation to HER2 expression, p53 mutation and estrogen and progesterone receptors
• Grantee: Sophie Françoise Mauricette Derchain
• Support Opportunities: Regular Research Grants