Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L.)

Autor(es)

Chaves, Juliana Siqueira ; da Costa, Fernando Batista ; Pedro de Freitas, Luis Alexandre ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, Lab Fis Ind, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 45, n. 3, p. 573-584, JUL-SEP 2009.
• Citações Web of Science: 10

Resumo

Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids So far. there are no studies on standardization of pie-formulations or phytomedicines containing this herb The present study aimed at developing a pre-formulation using a standardized spray-dried extract of feverfew and further designing and standardizing enteric coated tablets In this work, the spray-dried extract of feverfew was evaluated for its parthenolide. santin and total flavonoid content. parthenolide solubility. particle size. tapped density, hygroscopicity, angle of repose and moisture content. Tablets containing the spray-dried extract were tested for their average weight, friability. hardness. and disintegration time. The total flavonoid and parthenolide contents in the spray-dried extract were 1.31 % and 0.76% w/w, respectively The spray-dried extract presented consistent pharmacotechnical properties and allowed its tableting by direct compression Tablet properties were in accordance with the proposed specifications The procedures described herein can be Used to prepare and evaluate pre-formulations of feverfew with adequate properties for the development of a high-quality phytomedicine. (AU)

• Processo FAPESP: 01/12638-2 - Estudo farmacognóstico de Tanacetum parthenium (Asteraceae), para controle de qualidade de fitoterápicos, baseado em um sistema matricial de liberação sustentada com revestimento entérico
• Beneficiário: Juliana Siqueira Chaves
• Modalidade de apoio: Bolsas no Brasil - Doutorado