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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection

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Autor(es):
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Carlos, Daniela [1] ; Frantz, Fabiani G. [1] ; Souza-Junior, Devandir A. [2] ; Jamur, Maria C. [2] ; Oliver, Constance [2] ; Ramos, Simone G. [3] ; Quesniaux, Valerie F. [4] ; Ryffel, Bernhard [4] ; Silva, Celio L. [5] ; Bozza, Marcelo T. [6] ; Faccioli, Lucia H. [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular & Mol & Bioagentes Patogen, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Patol, BR-14040903 Ribeirao Preto, SP - Brazil
[4] CNRS, F-45071 Orleans - France
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14040903 Ribeirao Preto, SP - Brazil
[6] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo de Goes, Dept Imunol, BR-21941 Rio De Janeiro - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Microbes and Infection; v. 11, n. 8-9, p. 770-778, JUL-AUG 2009.
Citações Web of Science: 25
Resumo

Mast Cells (MCs) express toll-like receptor 2 (TLR2), a receptor known to be triggered by several major mycobacterial ligands and involved in resistance against Mycobacterium tuberculosis (MTB) infection. This study investigated whether adoptive transfer of TLR2 positive MCs (TLR2(+/+)) corrects the increased susceptibility of TLR2(-/-) mice to MTB infection. TLR2(-/-) mice displayed increased mycobacterial burden, diminished myeloid cell recruitment and proinflammatory cytokine production accompanied by defective granuloma formation. The reconstitution of these mice with TLR2(+/+) MCs, but not TLR2(-/-), confers better control of the infection, promotes the normalization of myeloid cell recruitment associated with reestablishment of the granuloma formation. In addition, adoptive transfer of TLR2(+/+) MC to TLR2(-/-) mice resulted in regulation of the pulmonary levels of IL-beta, IL-6, TNF-alpha, enhanced Th1 response and activated CD8(+) T cell homing to the lungs. Our results suggest that activation of MCs via TLR2 is required to compensate the defect in protective immunity and inability of TLR2(-/-) mice to control MTB infection. (C) 2009 Elsevier Masson SAS. All rights reserved. (AU)

Processo FAPESP: 03/12885-5 - Avaliação do papel de mastócitos na resposta imune na tuberculose experimental murina
Beneficiário:Daniela Carlos Sartori
Linha de fomento: Bolsas no Brasil - Doutorado