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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Immunogenicity of 23-valent pneumococcal polysaccharide vaccine in HIV-infected pregnant women and kinetics of passively acquired antibodies in young infants

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Autor(es):
Almeida, Volia De Carvalho [1] ; Mussi-Pinhata, Marisa Marcia [2] ; Sandoval De Souza, Cleonice Barbosa [2] ; Kubo, Christina Arslanian [3] ; Martinez, Edson Zangiacomi [4] ; Carneiro-Sampaio, Magda Maria [5] ; Duarte, Geraldo [6]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Biol & Hlth Sci Ctr, Dept Med, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Social Med, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Dept Pediat, Fac Med, BR-05403900 Sao Paulo - Brazil
[6] Univ Sao Paulo, Dept Gynecol & Obstet, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Vaccine; v. 27, n. 29, p. 3856-3861, JUN 12 2009.
Citações Web of Science: 12
Resumo

Whether gestational immunization of HIV-infected mothers with the 23-valent pneumococcal polysaccharide vaccine (PPV) confers maternal and infant early life, passive protection is not known. We evaluated safety, immunogenicity and placental transfer of antibodies in 44 HIV-infected women. Pneumococcal IgG antibodies against serotypes 1, 3, 5, 613, 9V, and 14 were measured in mothers (pre-vaccination and at delivery), and infants (at birth, 1, 2, 3, and 6 months). PPV was safe and immunogenic in mothers. Newborns received 46-72% of maternal antibody titers. Overall, infants had antibody levels lower than protective by 2 months of age. Alternative pneumococcal vaccination of HIV-infected pregnant women should be explored with the aim of prolonging passive protection in their infants. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 02/01294-3 - Imunização com a vacina pneumocócica durante a gestação em mulheres infecctadas pelo vírus da imunodeficiência humana (HIV): resposta vacinal materna e transmissão placentária de anticorpos específicos
Beneficiário:Marisa Marcia Mussi
Linha de fomento: Auxílio à Pesquisa - Regular