Differential cytokine expressions affect the severity of peri-implant disease

Autor(es)

Duarte, Poliana Mendes ^[1] ; de Mendonca, Adriana Cutrim ^[1] ; Braz Maximo, Maria Beatriz ^[1] ; Santos, Vanessa Renata ^[1] ; Bastos, Marta Ferreira ^[1] ; Nociti Junior, Francisco Humberto ^[2]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Sch Dent Piracicaba, Div Periodont, Dept Prosthodont Periodont, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Oral Implants Research; v. 20, n. 5, p. 514-520, MAY 2009.
• Citações Web of Science: 56

Resumo

Objective: This study assessed gene expression by quantitative polymerase chain reaction of inflammatory-{[}interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), IL-4, and IL-10] and osteoclastogenesis-related factors {[}receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites exhibiting different severities of peri-implant disease. Material and methods: Peri-implant soft tissue biopsies (n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) and severe peri-implantitis (SP) sites. Results: IL-12 and TNF-alpha mRNA levels were higher in SP, followed by IP and MC (P < 0.05). IL-4 was higher in HI, followed by MC, SP and IP (P < 0.05). IL-10 was the lowest in HI, while no differences were detected among the diseased groups (P=0.05). OPG mRNA levels were higher in HI, followed by IP, SP and MC, whereas RANKL was increased as the peri-implantitis severity increased (P < 0.05). The highest OPG/RANKL ratio was observed in HI and the lowest in SP (P < 0.01). Conclusion: These findings suggest that expressions of inflammatory- and osteoclastogenesis-related factors may play an important role in the onset and severity of the peri-implant diseases. (AU)

• Processo FAPESP: 06/04604-4 - Expressão de RANKL e osteoprotegerina no fluido e tecido gengival em diferentes severidades da perimplantite antes e após terapia anti-infecciosa: estudo em humanos
• Beneficiário: Vanessa Renata Santos da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 05/02561-3 - Perfis microbiológico e de expressão de citocinas pró- e anti-inflamatórias associados às diferentes severidades da perimplantite: estudo em humanos
• Beneficiário: Poliana Mendes Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular