Differential cytokine expressions affect the severity of peri-implant disease

Author(s)

Duarte, Poliana Mendes ^[1] ; de Mendonca, Adriana Cutrim ^[1] ; Braz Maximo, Maria Beatriz ^[1] ; Santos, Vanessa Renata ^[1] ; Bastos, Marta Ferreira ^[1] ; Nociti Junior, Francisco Humberto ^[2]

Affiliation

^[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Sch Dent Piracicaba, Div Periodont, Dept Prosthodont Periodont, Sao Paulo - Brazil

• Document type: Journal article
• Source: Clinical Oral Implants Research; v. 20, n. 5, p. 514-520, MAY 2009.
• Web of Science Citations: 56

Abstract

Objective: This study assessed gene expression by quantitative polymerase chain reaction of inflammatory-{[}interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), IL-4, and IL-10] and osteoclastogenesis-related factors {[}receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites exhibiting different severities of peri-implant disease. Material and methods: Peri-implant soft tissue biopsies (n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) and severe peri-implantitis (SP) sites. Results: IL-12 and TNF-alpha mRNA levels were higher in SP, followed by IP and MC (P < 0.05). IL-4 was higher in HI, followed by MC, SP and IP (P < 0.05). IL-10 was the lowest in HI, while no differences were detected among the diseased groups (P=0.05). OPG mRNA levels were higher in HI, followed by IP, SP and MC, whereas RANKL was increased as the peri-implantitis severity increased (P < 0.05). The highest OPG/RANKL ratio was observed in HI and the lowest in SP (P < 0.01). Conclusion: These findings suggest that expressions of inflammatory- and osteoclastogenesis-related factors may play an important role in the onset and severity of the peri-implant diseases. (AU)

• FAPESP's process: 06/04604-4 - RANKL and osteoprotegerin expression in gingival fluid and tissue in different peri-implantitis severity before and after anti-infection therapy: a study in human beings
• Grantee: Vanessa Renata Santos da Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 05/02561-3 - Microbiological and pro-inflammatory and anti-inflammatory cytokine expression profiles in different forms of human peri-implantitis
• Grantee: Poliana Mendes Duarte
• Support Opportunities: Regular Research Grants