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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential cytokine expressions affect the severity of peri-implant disease

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Duarte, Poliana Mendes [1] ; de Mendonca, Adriana Cutrim [1] ; Braz Maximo, Maria Beatriz [1] ; Santos, Vanessa Renata [1] ; Bastos, Marta Ferreira [1] ; Nociti Junior, Francisco Humberto [2]
Total Authors: 6
[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Sch Dent Piracicaba, Div Periodont, Dept Prosthodont Periodont, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Clinical Oral Implants Research; v. 20, n. 5, p. 514-520, MAY 2009.
Web of Science Citations: 56

Objective: This study assessed gene expression by quantitative polymerase chain reaction of inflammatory-{[}interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), IL-4, and IL-10] and osteoclastogenesis-related factors {[}receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG)] in sites exhibiting different severities of peri-implant disease. Material and methods: Peri-implant soft tissue biopsies (n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) and severe peri-implantitis (SP) sites. Results: IL-12 and TNF-alpha mRNA levels were higher in SP, followed by IP and MC (P < 0.05). IL-4 was higher in HI, followed by MC, SP and IP (P < 0.05). IL-10 was the lowest in HI, while no differences were detected among the diseased groups (P=0.05). OPG mRNA levels were higher in HI, followed by IP, SP and MC, whereas RANKL was increased as the peri-implantitis severity increased (P < 0.05). The highest OPG/RANKL ratio was observed in HI and the lowest in SP (P < 0.01). Conclusion: These findings suggest that expressions of inflammatory- and osteoclastogenesis-related factors may play an important role in the onset and severity of the peri-implant diseases. (AU)

FAPESP's process: 05/02561-3 - Microbiological and pro-inflammatory and anti-inflammatory cytokine expression profiles in different forms of human peri-implantitis
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants
FAPESP's process: 06/04604-4 - RANKL and osteoprotegerin expression in gingival fluid and tissue in different peri-implantitis severity before and after anti-infection therapy: a study in human beings
Grantee:Vanessa Renata Santos da Silva
Support type: Scholarships in Brazil - Master