Endophytic fungi found in association with Smallanthus sonchifolius (Asteraceae) as resourceful producers of cytotoxic bioactive natural products

Autor(es):Mostrar menos -

Gallo, Margareth B. C. ^[1] ; Chagas, Fernanda O. ^[1] ; Almeida, Marilia O. ^[1] ; Macedo, Claudia C. ^[1] ; Cavalcanti, Bruno C. ^[2] ; Barros, Francisco W. A. ^[2] ; de Moraes, Manoel O. ^[2] ; Costa-Lotufo, Leticia V. ^[2] ; Pessoa, Claudia ^[2] ; Bastos, Jairo K. ^[1] ; Pupo, Monica T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, Ceara - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BASIC MICROBIOLOGY; v. 49, n. 2, p. 142-151, APR 2009.
• Citações Web of Science: 25

Resumo

Smallanthus sonchifolius is a traditional Andean plant which has been cultured mainly in Brazil, Japan and New Zealand due to its medicinal properties. A study of the endophytic fungi associated to the plant was carried out in order to characterize new cytotoxic agents. Thirty two fungal strains were isolated and submitted to cultivation and extraction producing 186 extracts. Of these, 12% displayed moderate to high cytotoxic activities and were considered promising anticancer compound sources. The ethyl acetate fractions of Nigrospora sphaerica and Phoma betae liquid fermentations contained the synergistic compounds 8-hydroxy-6-methoxy-3-methylisocoumarin and (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one which are potential compounds for drug discovery. Another isolated compound, pimara-7,15-dien-3-beta-ol diterpene is being characterized for the first time through a detailed spectroscopic analysis including GC/MS, homo- and hetero-nuclear correlated NMR experiments (HMQC, HMBC, COSY and NOEdiff) along with its optical rotation. (AU)

• Processo FAPESP: 05/56259-6 - Busca de microganismos endofilicos e seus produtos naturais bioativos em Smallanthus sonchifolius Poepp. & Endl. (Asteraceae)
• Beneficiário: Margareth Borges Coutinho Gallo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 04/07935-6 - Bioprospecção de fungos: a busca de compostos importantes para o projeto de remédios e enzimas para aplicações farmacêuticas e industriais
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático