| Full text | |
| Author(s): Show less - |
Gallo, Margareth B. C.
[1]
;
Chagas, Fernanda O.
[1]
;
Almeida, Marilia O.
[1]
;
Macedo, Claudia C.
[1]
;
Cavalcanti, Bruno C.
[2]
;
Barros, Francisco W. A.
[2]
;
de Moraes, Manoel O.
[2]
;
Costa-Lotufo, Leticia V.
[2]
;
Pessoa, Claudia
[2]
;
Bastos, Jairo K.
[1]
;
Pupo, Monica T.
[1]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, Ceara - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF BASIC MICROBIOLOGY; v. 49, n. 2, p. 142-151, APR 2009. |
| Web of Science Citations: | 25 |
| Abstract | |
Smallanthus sonchifolius is a traditional Andean plant which has been cultured mainly in Brazil, Japan and New Zealand due to its medicinal properties. A study of the endophytic fungi associated to the plant was carried out in order to characterize new cytotoxic agents. Thirty two fungal strains were isolated and submitted to cultivation and extraction producing 186 extracts. Of these, 12% displayed moderate to high cytotoxic activities and were considered promising anticancer compound sources. The ethyl acetate fractions of Nigrospora sphaerica and Phoma betae liquid fermentations contained the synergistic compounds 8-hydroxy-6-methoxy-3-methylisocoumarin and (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one which are potential compounds for drug discovery. Another isolated compound, pimara-7,15-dien-3-beta-ol diterpene is being characterized for the first time through a detailed spectroscopic analysis including GC/MS, homo- and hetero-nuclear correlated NMR experiments (HMQC, HMBC, COSY and NOEdiff) along with its optical rotation. (AU) | |
| FAPESP's process: | 05/56259-6 - Search for endophylic microorganisms and their natural bioactive products in Smallanthus sonchifolius Poepp. & Endl. (Asteraceae) |
| Grantee: | Margareth Borges Coutinho Gallo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 04/07935-6 - Bioprospection in fungi: the search of lead compounds for drug design and enzymes for pharmaceutical and industrial applications |
| Grantee: | Jairo Kenupp Bastos |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |