Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease?

Autor(es)

Rodrigues, M. M. ^[1] ; de Alencar, B. C. G. ^[1] ; Claser, C. ^[1] ; Tzelepis, F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, EPM, CINTERGEN, BR-04044010 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 42, n. 3, p. 220-223, MAR 2009.
• Citações Web of Science: 13

Resumo

Intense immune responses are observed during human or experimental infection with the digenetic protozoan parasite Trypanosoma cruzi. The reasons why such immune responses are unable to completely eliminate the parasites are unknown. The survival of the parasite leads to a parasite-host equilibrium found during the chronic phase of chagasic infection in most individuals. Parasite persistence is recognized as the most likely cause of the chagasic chronic pathologies. Therefore, a key question in Chagas' disease is to understand how this equilibrium is established and maintained for a long period. Understanding the basis for this equilibrium may lead to new approaches to interventions that could help millions of individuals at risk for infection or who are already infected with T. cruzi. Here, we propose that the phenomenon of immunodominance may be significant in terms of regulating the host-parasite equilibrium observed in Chagas' disease. T. cruzi infection restricts the repertoire of specific T cells generating, in some cases, an intense immunodominant phenotype and in others causing a dramatic interference in the response to distinct epitopes. This immune response is sufficiently strong to maintain the host alive during the acute phase carrying them to the chronic phase where transmission usually occurs. At the same time, immunodominance interferes with the development of a higher and broader immune response that could be able to completely eliminate the parasite. Based on this, we discuss how we can interfere with or take advantage of immunodominance in order to provide an immunotherapeutic alternative for chagasic individuals. (AU)

• Processo FAPESP: 03/09675-9 - Análise do impacto na resposta imune do polimorfismo da proteína 2 da superfície de amastigotas (ASP-2) expressa em diferentes cepas das linhagens filogeneticamente 1 e 2 de Trypanosoma cruzi
• Beneficiário: Carla Claser
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 03/09672-0 - Estudo da função dos linfócitos T CD8 específicos para os antígenos ASP-2, LYT1 e trans-sialidase na infecção experimental pelo Trypanosoma cruzi
• Beneficiário: Fanny Tzelepis
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto