| Texto completo | |
| Autor(es): |
Crestani, Carlos C.
[1]
;
Tavares, Rodrigo F.
[1]
;
Alves, Fernando H. F.
[1]
;
Resstel, Leonardo B. M.
[1]
;
Correa, Fernando M. A.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience Letters; v. 448, n. 2, p. 189-193, DEC 26 2008. |
| Citações Web of Science: | 15 |
| Resumo | |
The diagonal band of Broca (DBB) is involved in cardiovascular control in rats, In the present Study, we report the effect of acute and reversible neurotransmission inhibition in the DBB by bilateral microinjection of the nonselective neurotransmission blocker CoCl(2) (1 mM, 100 nL) on the cardiac baroreflex response in unanesthetized rats. Local DBB neurotransmission inhibition did not affect baseline values of either blood pressure or heart rate, Suggesting no tonic DBB influence oil cardiovascular system activity. However, CoCl(2) microinjections enhanced both the reflex bradycardia associated with blood pressure increases caused by i.v. infusion of phenylephrine and tachycardiac response evoked by blood pressure decreases caused by i.v. infusion of sodium nitroprusside. An increase in baroreflex gain was also observed. Baroreflex returned to control values 60 min after CoCl(2) microinjections, confirming its reversible effect. In conclusion, our data suggest that synapses within DBB have a tonic inhibitory influence on both the cardiac parasympathetic and sympathetic components of the baroreflex. (C) 2008 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 06/57670-4 - Estudo da participação da neurotransmissão noradrenérgica do núcleo leito da estria terminal na regulação do sistema cardiovascular em ratos |
| Beneficiário: | Carlos Cesar Crestani |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |