Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population

Autor(es)

Freitas, Silvia R. ^{[1, 2]} ; Pereira, Alexandre C. ^[1] ; Floriano, Marcilene S. ^[1] ; Mill, Jose G. ^[3] ; Krieger, Jose E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, Sao Paulo - Brazil

^[2] Fiocruz MS, Inst Oswaldo Cruz, Lab Human Genet, BR-21045900 Rio De Janeiro - Brazil

^[3] Univ Fed Espirito Santo, Dept Physiol, Vitoria - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC CARDIOVASCULAR DISORDERS; v. 8, DEC 23 2008.
• Citações Web of Science: 17

Resumo

Background: The alpha1A-adrenergic receptor (alpha(1A)-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we aimed to investigate the association between the Arg347Cys polymorphism in the alpha(1A)-AR gene and blood pressure phenotypes, in a large sample of Brazilians from an urban population. Methods: A total of 1568 individuals were randomly selected from the general population of the Vitoria City metropolitan area. Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate comparisons and logistic regression for multivariate comparisons. Results: Association analysis indicated a significant difference between genotype groups with respect to diastolic blood pressure (p = 0.04), but not systolic blood pressure (p = 0.12). In addition, presence of the Cys/Cys genotype was marginally associated with hypertension in our population (p = 0.06). Significant interaction effects were observed between the studied genetic variant, age and physical activity. Presence of the Cys/Cys genotype was associated with hypertension only in individuals with regular physical activity (odds ratio = 1.86; p = 0.03) or younger than 45 years (odds ratio = 1.27; p = 0.04). Conclusion: Physical activity and age may potentially play a role by disclosing the effects of the Cys allele on blood pressure. According to our data it is possible that the Arg347Cys polymorphism can be used as a biomarker to disease risk in a selected group of individuals. (AU)

• Processo FAPESP: 01/03454-5 - Determinantes genéticos da concentração plasmática da proteína C reativa em indivíduos sem evidência de cardiopatia
• Beneficiário: Alfredo José Mansur
• Modalidade de apoio: Auxílio à Pesquisa - Regular