Lithium thiazolidine-4-carboxylate: Synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells

Autor(es)

Corbi, Pedro P. ^{[1, 2]} ; Andrade, Fabiana C. ^[1] ; Massabni, Antonio C. ^[1] ; Heinrich, Tassiele A. ^[3] ; Souza, Pedro P. C. ^[3] ; Costa-Neto, Claudio M. ^[3]

Afiliação do(s) autor(es)

^[1] UNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP - Brazil

^[2] Ctr Univ Araraquara UNIARA, Assoc Sao Bento De Ensino, Dept Ciencias Biol & Saude, BR-14801320 Araraquara, SP - Brazil

^[3] USP, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 71, n. 3, p. 929-931, DEC 1 2008.
• Citações Web of Science: 3

Resumo

A new water-soluble lithium Salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques, Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1)H, (13)C nuclear magnetic resonance (NMR). {[}(1)H-(15)N] NMR and infrared (IR) analyses permitted to elucidate the structure Of the compound. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium Salt colorimetric assay, which reflects the cells viability. (C) 2008 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 07/56317-1 - Complexos metalicos de platina(ii), platina(iv), paladio(ii), ouro(i) e ouro(iii) com aminoacidos e derivados: sintese, casracterizacao e aplicacoes farmacologicas.
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 06/55367-2 - Complexos metálicos de platina (II), platina (IV), paládio (II), ouro (I) e ouro (III) com aminoácidos e derivados: síntese, caracterização e aplicações farmacológicas
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores