Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lithium thiazolidine-4-carboxylate: Synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells

Full text
Author(s):
Corbi, Pedro P. [1, 2] ; Andrade, Fabiana C. [1] ; Massabni, Antonio C. [1] ; Heinrich, Tassiele A. [3] ; Souza, Pedro P. C. [3] ; Costa-Neto, Claudio M. [3]
Total Authors: 6
Affiliation:
[1] UNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP - Brazil
[2] Ctr Univ Araraquara UNIARA, Assoc Sao Bento De Ensino, Dept Ciencias Biol & Saude, BR-14801320 Araraquara, SP - Brazil
[3] USP, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 71, n. 3, p. 929-931, DEC 1 2008.
Web of Science Citations: 3
Abstract

A new water-soluble lithium Salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques, Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1)H, (13)C nuclear magnetic resonance (NMR). {[}(1)H-(15)N] NMR and infrared (IR) analyses permitted to elucidate the structure Of the compound. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium Salt colorimetric assay, which reflects the cells viability. (C) 2008 Elsevier B.V. All rights reserved. (AU)