Casein kinase I epsilon (CKI epsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders

Autor(es)

Castro, Rosa M. R. P. S. ^[1] ; Barbosa, Ana A. ^[1] ; Pedrazzoli, Mario ^[1] ; Tufik, Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, UNIFESP, Dept Psychobiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 193, n. 1, p. 156-157, NOV 3 2008.
• Citações Web of Science: 8

Resumo

Circadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKI epsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this phosphorylation has been implicated in human sleep disorders. Here, we investigated the CKI epsilon S408N polymorphism in a Brazilian population sample. The N408 allele was previously described to be much less frequent in individuals with Delayed Sleep-Phase Syndrome (DSPS), than in the general Japanese population, Suggesting a protective function for the allele against the disease. We found that this polymorphism is very rare in the Brazilian population (1.37%), indicating that it has no influence on susceptibility to circadian rhythm sleep disorders. Therefore, it is necessary to account for adaptative influences in genetic background, analyzing different groups with different photoperiods, to validate the effects of this and other polymorphisms on sleep and circadian disorders. (C) 2008 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/58104-2 - Genética epidemiológica do sono: análise da influência de polimorfismos nos genes Reverb alfa e Bmal1 na determinação dos cronotipos matutinos e vespertinos em uma amostra da população brasileira
• Beneficiário: Rosa Maria Rodrigues Pinto Santos Castro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado