Experimental infection of dogs with a Brazilian strain of Rickettsia rickettsii: clinical and laboratory findings

Autor(es)

Piranda, Eliane M. y ^[1] ; Faccini, Joao Luis H. ^[1] ; Pinter, Adriano ^[2] ; Saito, Tais B. ^[3] ; Pacheco, Richard C. ^[4] ; Hagiwara, Mitika K. ^[3] ; Labruna, Marcelo B. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Rural Rio de Janeiro, Inst Vet, Dept Parasitol Anim, Seropedica, RJ - Brazil

^[2] Superintendencia Controle Endemias Estado Sao Paul, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508270 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Memórias do Instituto Oswaldo Cruz; v. 103, n. 7, p. 696-701, NOV 2008.
• Citações Web of Science: 47

Resumo

The bacterium Rickettsia rickettsii is the etiological agent of an acute, severe disease called Rocky Mountain spotted fever in the United States or Brazilian spotted fever (BSF) in Brazil. In addition to these two countries, the disease has also been reported to affect humans in Mexico, Costa Rica, Panama, Colombia and Argentina. Like humans, dogs are also susceptible to R. rickettsii infection. However, despite the wide distribution of R. rickettsii in the Western Hemisphere, reports of R. rickettsii-induced illness in dogs has been restricted to the United States. The present study evaluated the pathogenicity for dogs of a South American strain of R. rickettsii. Three groups of dogs were evaluated: group 1 (G1) was inoculated ip with R. rickettsii; group 2 (G2) was infested by R. rickettsii-infected ticks; and the control group (G3) was infested by uninfected ticks. During the study, no clinical abnormalities, Rickettsia DNA or R. rickettsii-reactive antibodies were detected in G3. In contrast, all G1 and G2 dogs developed signs of rickettsial infection, i.e., fever, lethargy, anorexia, ocular lesions, thrombocytopenia, anemia and detectable levels of Rickettsia DNA and R. rickettsii-reactive antibodies in their blood. Rickettsemia started 3-8 days after inoculation or tick infestation and lasted for 3-13 days. Our results indicate that a Brazilian strain of R. rickettsii is pathogenic for dogs, suggesting that canine clinical illness due to R. rickettsii has been unreported in Brazil and possibly in the other South American countries where BSF has been reported among humans. (AU)

• Processo FAPESP: 06/50918-0 - Avaliação do papel das capivaras (Hydrochoerus hydrochaeris), gambás (Didelphis aurita) e cães domésticos na epidemiologia da febre maculosa brasileira
• Beneficiário: Marcelo Bahia Labruna
• Modalidade de apoio: Auxílio à Pesquisa - Regular