Risk factors for dengue virus infection in rural Amazonia: Population-based cross-sectional surveys

Autor(es):Mostrar menos -

da Silva-Nunes, Monica ^[1] ; de Souza, Vanda A. F. ^[2] ; Pannuti, Claudio S. ^[2] ; Speranca, Marcia A. ^[2] ; Terzian, Ana Carolina B. ^[2] ; Nogueira, Mauricio L. ^[2] ; Yamamura, Anna M. Y. ^[2] ; Freire, Marcos S. ^[2] ; da Silva, Natal S. ^[2] ; Malafronte, Rosely S. ^[2] ; Muniz, Pascoal T. ^[2] ; Vasconcelos, Helena B. ^[2] ; da Silva, Eliana V. P. ^[2] ; Vasconcelos, Pedro F. C. ^[2] ; Ferreira, Marcelo U. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo - Brazil

^[2] Evandro Chagas Inst, Lab Arbovirol & Hemorrhag Fevers, BR-66093020 Belem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 79, n. 4, p. 485-494, OCT 2008.
• Citações Web of Science: 18

Resumo

A comparison of dengue virus (DENV) antibody levels in paired serum samples collected from predominantly DENV-naive residents in an agricultural settlement in Brazilian Amazonia (baseline seroprevalence, 18.3%) showed a seroconversion rate of 3.67 episodes/100 person-years at risk during 12 months of follow-up. Multivariate analysis identified male sex, poverty, and migration from extra-Amazonian states as significant predictors of baseline DENY seropositivity, whereas male sex, a history of clinical diagnosis of dengue fever, and travel to an urban area predicted subsequent seroconversion. The laboratory surveillance of acute febrile illnesses implemented at the study site and in a nearby town between 2004 and 2006 confirmed 11. DENV infections among 102 episodes studied with DENV IgM detection, reverse transcriptase-polymerise chain reaction, and virus isolation; DENV-3 was isolated. Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population. (AU)

• Processo FAPESP: 04/00373-2 - Dinâmica de transmissão da dengue e outras arboviroses em área rural e seus determinantes: estudo longitudinal na Amazônia Ocidental brasileira
• Beneficiário: Marcelo Urbano Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular