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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Risk factors for dengue virus infection in rural Amazonia: Population-based cross-sectional surveys

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Author(s):
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da Silva-Nunes, Monica [1] ; de Souza, Vanda A. F. [2] ; Pannuti, Claudio S. [2] ; Speranca, Marcia A. [2] ; Terzian, Ana Carolina B. [2] ; Nogueira, Mauricio L. [2] ; Yamamura, Anna M. Y. [2] ; Freire, Marcos S. [2] ; da Silva, Natal S. [2] ; Malafronte, Rosely S. [2] ; Muniz, Pascoal T. [2] ; Vasconcelos, Helena B. [2] ; da Silva, Eliana V. P. [2] ; Vasconcelos, Pedro F. C. [2] ; Ferreira, Marcelo U. [2]
Total Authors: 15
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo - Brazil
[2] Evandro Chagas Inst, Lab Arbovirol & Hemorrhag Fevers, BR-66093020 Belem, Para - Brazil
Total Affiliations: 2
Document type: Journal article
Source: American Journal of Tropical Medicine and Hygiene; v. 79, n. 4, p. 485-494, OCT 2008.
Web of Science Citations: 18
Abstract

A comparison of dengue virus (DENV) antibody levels in paired serum samples collected from predominantly DENV-naive residents in an agricultural settlement in Brazilian Amazonia (baseline seroprevalence, 18.3%) showed a seroconversion rate of 3.67 episodes/100 person-years at risk during 12 months of follow-up. Multivariate analysis identified male sex, poverty, and migration from extra-Amazonian states as significant predictors of baseline DENY seropositivity, whereas male sex, a history of clinical diagnosis of dengue fever, and travel to an urban area predicted subsequent seroconversion. The laboratory surveillance of acute febrile illnesses implemented at the study site and in a nearby town between 2004 and 2006 confirmed 11. DENV infections among 102 episodes studied with DENV IgM detection, reverse transcriptase-polymerise chain reaction, and virus isolation; DENV-3 was isolated. Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population. (AU)