Brazilian propolis: Correlation between chemical composition and antimicrobial activity

Autor(es)

Salomao, Kelly ^[1] ; Pereira, Paulo Roberto S. ^[1] ; Campos, Leila C. ^[2] ; Borba, Cintia M. ^[3] ; Cabello, Pedro H. ^[4] ; Marcucci, Maria Cristina ^[5] ; de Castro, Solange L. ^[1]

Afiliação do(s) autor(es)

^[1] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Dept Ultraestrutura & Biol Celular, BR-21045900 Rio De Janeiro - Brazil

^[2] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Dept Bacteriol, BR-21045900 Rio De Janeiro - Brazil

^[3] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Dept Micol, BR-21045900 Rio De Janeiro - Brazil

^[4] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Dept Genet, BR-21045900 Rio De Janeiro - Brazil

^[5] Univ Bandeirante Sao Paulo, Nucleo Posgrad Pesquisa & Extensao, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Evidence-based Complementary and Alternative Medicine; v. 5, n. 3, p. 317-324, SEP 2008.
• Citações Web of Science: 62

Resumo

The chemical composition of ethanol extracts from samples of Brazilian propolis (EEPs) determined by HPLC and their activity against Trypanosoma cruzi, Staphylococcus aureus, Streptococcus pneumoniae, Klebisiella pneumoniae, Candida albicans, Sporothrix schenckii and Paracoccidioides brasiliensis were determined. Based on the predominant botanical origin in the region of samples' collection, the 10 extracts were separated into three groups: A (B. dracunculifolia + Auraucaria spp), B (B. dracunculifolia) and C (Araucaria spp). Analysis by the multiple regression of all the extracts together showed a positive correlation, higher concentrations leading to higher biological effect, of S. aureus with p-coumaric acid (PCUM) and 3-(4-hydroxy-3-(oxo-butenyl)-phenylacrylic acid (DHCA1) and of trypomastigotes of T. cruzi with 3,5-diprenyl-4-hydroxycinnamic acid derivative 4 (DHCA4) and 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyran (DCBEN). When the same approach was employed for each group, due to the small number of observations, the statistical test gave unreliable results. However, an overall analysis revealed for group A an association of S. aureus with caffeic acid (CAF) and dicaffeoylquinic acid 3 (CAFQ3), of S. pneumoniae with CAFQ3 and monocaffeoylquinic acid 2 (CAFQ2) and of T. cruzi also with CAFQ3. For group B, a higher activity against S. pneumoniae was associated DCBEN and for T. cruzi with CAF. For group C no association was observed between the anitmicrobial effect and any component of the extracts. The present study reinforces the relevance of PCUM and derivatives, especially prenylated ones and also of caffeolyquinic acids, on the biological activity of Brazilian propolis. (AU)

• Processo FAPESP: 00/10031-0 - Processo de identificação de tipagens da própolis brasileira
• Beneficiário: Maria Cristina Marcucci Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Programa de Apoio à Propriedade Intelectual (PAPI/Nuplitec)