Prevention and reversion of nonalcoholic steatohepatitis in ob/ob mice by S-nitroso-N-acetylcysteine treatment

Autor(es)

de Oliveira, Claudia P. M. S. ^[1] ; de Lima, Vicencia M. R. ; Simplicio, Fernanda I. ^[2] ; Soriano, Francisco G. ^[3] ; de Mello, Evandro S. ^[4] ; de Souza, Heraldo P. ^{[5, 3]} ; Alves, Venancio A. F. ^[4] ; Laurindo, Francisco R. M. ^[5] ; Carrilho, Flair J. ; de Oliveira, Marcelo G. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Gastroenterol, Inst Cent, Sch Med, BR-05403000 Sao Paulo - Brazil

^[2] State Univ Campinas UNICAMP, Inst Chem, Campinas, SP - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Emergency, BR-05403000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Pathol, BR-05403000 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Inst Heart, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION; v. 27, n. 2, p. 299-305, APR 2008.
• Citações Web of Science: 24

Resumo

Objective: To evaluate the role oral administration of S-nitroso-N-acetylcysteine (SNAC), a NO donor drug, in the prevention and reversion of NASH in two different animal models. Methods: NASH was induced in male ob/ob mice by methionine-choline deficient (MCD) and high-fat (H) diets. Two animal groups received or not SNAC orally for four weeks since the beginning of the treatment. Two other groups were submitted to MCD and H diets for 60 days receiving SNAC only from the 31(st) to the 60(th) day. Results: SNAC administration inhibited the development of NASH in all groups, leading to a marked decrease in macro and microvacuolar steatosis and in hepatic lipid peroxidation in the MCD group. SNAC treatment reversed the development of NASH in animals treated for 60 days with MCD or H diets, which received SNAC only from the 31(st) to the 60(th) day. Conclusions: Oral administration of SNAC markedly inhibited and reversed NASH induced by MCD and H diets in ob/ob mice. (AU)

• Processo FAPESP: 04/04483-7 - Estresse oxidativo e doenca nao alcoolica gordurosa do figado (nafld) em modelos animais: implicacoes fisiopatogenicas e terapeuticas.
• Beneficiário: Claudia Pinto Marques Souza de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular