Absence of mutagenicity effects of Psidium cattleyanum Sabine (Myrtaceae) extract on peripheral blood and bone marrow cells of mice

Autor(es)

Costa, T. D. A. ^[1] ; Vieira, S. ^[1] ; Andrade, S. F. ^[2] ; Maistro, E. L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP - Brazil

^[2] Univ Vale Itajai, Nucleo Invest Quimicofarmaceut, Itajai, SC - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Genetics and Molecular Research; v. 7, n. 3, p. 679-686, 2008.
• Citações Web of Science: 6

Resumo

Cattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum leaf extract was tested at concentrations of 1000, 1500 and 2000 mg/kg. N-nitroso-N-ethylurea was used as a positive control. Peripheral blood leukocytes were collected 4 and 24 h after the treatments for the comet assay, and bone marrow cells were collected after 24 and 48 h for the micronucleus test. Unlike N-nitroso-N-ethylurea, P. cattleyanum extract failed to induce a significant increase in cell DNA damage, in micronucleated cell frequency, and in bone marrow toxicity. The lack of mutagenicity and cytotoxicity with high doses of this plant extract means that it can be safely used in traditional medicine. (AU)

• Processo FAPESP: 06/57514-2 - Avaliacao do potencial mutagenico dos extratos de clusia alata e psidium cattleyanum em celulas de roedores in vivo.
• Beneficiário: Edson Luis Maistro
• Modalidade de apoio: Auxílio à Pesquisa - Regular