Involvement of the lateral septal area in the expression of fear conditioning to context

Autor(es)

Reis, Daniel G. ^[1] ; Scopinho, America A. ^[1] ; Guimaraes, Francisco S. ^[1] ; Correa, Fernando M. A. ^[1] ; Resstel, Leonardo B. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: LEARNING & MEMORY; v. 17, n. 3, p. 134-138, MAR 2010.
• Citações Web of Science: 20

Resumo

Considering the evidence that the lateral septal area (LSA) modulates defensive responses, the aim of the present study is to verify if this structure is also involved in contextual fear conditioning responses. Neurotransmission in the LSA was reversibly inhibited by bilateral microinjections of cobalt chloride (CoCl(2), 1 mM) 10 min before or after conditioning or 10 min before re-exposure to the aversively conditioned chamber. Only those animals that received CoCl(2) before re-exposure showed a decrease in both cardiovascular and behavioral conditioned responses. These results suggest that the LSA participates in the expression, but not acquisition or consolidation, of contextual fear conditioning. (AU)

• Processo FAPESP: 08/04069-7 - Estudo da participação do sistema colinérgico da área septal lateral na modulação de respostas cardiovasculares e comportamentais durante situações aversivas
• Beneficiário: Daniel Gustavo dos Reis
• Modalidade de apoio: Bolsas no Brasil - Doutorado