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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of the lateral septal area in the expression of fear conditioning to context

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Author(s):
Reis, Daniel G. [1] ; Scopinho, America A. [1] ; Guimaraes, Francisco S. [1] ; Correa, Fernando M. A. [1] ; Resstel, Leonardo B. M. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: LEARNING & MEMORY; v. 17, n. 3, p. 134-138, MAR 2010.
Web of Science Citations: 20
Abstract

Considering the evidence that the lateral septal area (LSA) modulates defensive responses, the aim of the present study is to verify if this structure is also involved in contextual fear conditioning responses. Neurotransmission in the LSA was reversibly inhibited by bilateral microinjections of cobalt chloride (CoCl(2), 1 mM) 10 min before or after conditioning or 10 min before re-exposure to the aversively conditioned chamber. Only those animals that received CoCl(2) before re-exposure showed a decrease in both cardiovascular and behavioral conditioned responses. These results suggest that the LSA participates in the expression, but not acquisition or consolidation, of contextual fear conditioning. (AU)

FAPESP's process: 08/04069-7 - Study of the involvement of the lateral septal area cholinergic system in cardiovascular and behavioral modulation responses during aversive situations
Grantee:Daniel Gustavo dos Reis
Support Opportunities: Scholarships in Brazil - Doctorate