The relationship between cortisol concentrations in pregnancy and systemic vascular resistance in childhood

Autor(es)

Carvalho Rondo, Patricia Helen ^[1] ; Lemos, Jesuana Oliveira ^[1] ; Pereira, Joilane Alves ^[1] ; Pacheco Souza, Jose Maria ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Stat & Epidemiol Dept, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EARLY HUMAN DEVELOPMENT; v. 86, n. 2, p. 127-131, FEB 2010.
• Citações Web of Science: 12

Resumo

Objective To assess the relationship between cortisol concentrations in the last trimester of pregnancy and systemic vascular resistance - SVR in childhood Materials and methods This study is part of a cohort involving 130 Brazilian pregnant women and their children, ages 5 to 7 years. Maternal cortisol was determined in saliva by an enzyme immunoassay utilizing the mean concentration of 9 samples of saliva (3 in each different day), collected at the same time, early in the morning. SVR was assessed by the HDI/PulseWave CR-2000 Cardiovascular Profiling System (R) Socioeconomic and demographic characteristics and life style factors were determined by a questionnaire The nutritional status of the women and children was assessed by the body mass index - BMI The association between maternal cortisol and SVR in childhood was calculated by multivariate linear regression analysis. Results: There were statistically significant associations between maternal cortisol and SVR (p = 0 043) and BMI-z score of the children (p = 0027). controlling for maternal BMI, birth weight, age, and gender of the children Conclusion As far as we know this is the first study in the literature assessing the association between cortisol concentrations in pregnancy and SVR in childhood Overall, the data suggest that exposure to excess glucocorticoid in the prenatal period is associated to vascular complications in childhood, predisposing to cardiovascular diseases in later life (C) 2010 Elsevier Ireland Ltd All rights reserved (AU)

• Processo FAPESP: 04/04109-8 - Efeito do peso ao nascimento no desenvolvimento de resistência à insulina, obesidade e hipertensão em crianças de 3 a 6 anos de idade no município de Jundiaí, São Paulo
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular