| Texto completo | |
| Autor(es): |
Coutinho Gallo, Margareth Borges
[1]
;
Cavalcanti, Bruno Coelho
[2]
;
Araujo Barros, Francisco Washington
[2]
;
de Moraes, Manoel Odorico
[2]
;
Costa-Lotufo, Leticia Veras
[2]
;
Pessoa, Claudia
[2]
;
Bastos, Jairo Kenupp
[1]
;
Pupo, Monica Tallarico
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, CE - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRY & BIODIVERSITY; v. 7, n. 12, p. 2941-2950, 2010. |
| Citações Web of Science: | 14 |
| Resumo | |
Papulaspora immersa H. H. HOTS ON was isolated from roots and leaves of Smallanthus sonchifolius (POEPP. and ENDL.) H. ROB. (Asteraceae), traditionally known as Yacon. The fungus was cultured in rice, and, from the AcOEt fraction, 14 compounds were isolated. Among them, (22E,24R)-8,14-epoxyergosta-4,22-diene-3,6-dione (4), 2,3-epoxy-1,2,3,4-tetrahydronaphthalene-c-1,c-4,8-triol (10), and the chromone papulasporin (13) were new secondary metabolites. The spectral data of the known natural products were compared with the literature data, and their structures were established as the (24R)stigmast 4 en 3 one (1), 24-methylenecycloartan-3 beta-ol (2), (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (3), (-)-(3R,4R)-4-hydroxymellein (5), (-)-(3R)-5-hydroxymellein (6), 6,8-dihydroxy-3-methylisocoumarin (7), (-)-(4S)-4,8-dihydroxy-alpha-tetralone (8), naphthalene-1,8-diol (9), 6,7,8-trihydroxy-3-methylisocoumarin (11), 7-hydroxy-2,5-dimethylchromone (12), and tyrosol (14). Compound 4 showed the highest cytotoxic activity against the human tumor cell lines MDA-MB435 (melanoma), HCT-8 (colon), SF295 (glioblastoma), and HL-60 (promyelocytic leukemia), with IC50 values of 3.3, 14.7, 5.0 and 1.6 mu m, respectively. Strong synergistic effects were also observed with compound 5 and some of the isolated steroidal compounds. (AU) | |
| Processo FAPESP: | 08/09540-0 - Novas estratégias na pesquisa em antibióticos naturais: microrganismos simbiontes como fontes de substâncias e ensaio in vivo baseado no modelo de infecção em Caenorhabditis elegans |
| Beneficiário: | Mônica Tallarico Pupo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 04/07935-6 - Bioprospection in fungi: the search of lead compounds for drug design and enzymes for pharmaceutical and industrial applications. |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |
| Processo FAPESP: | 05/56259-6 - Busca de microganismos endofilicos e seus produtos naturais bioativos em smallanthus sonchifolius poepp. & endi. (asteraceae). |
| Beneficiário: | Margareth Borges Coutinho Gallo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |