Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12

Autor(es)

Brassesco, Maria Sol ^[1] ; Valera, Elvis Terci ^[1] ; Neder, Luciano ^[2] ; Castro-Gamero, Angel Mauricio ^[3] ; de Oliveira, Fabio Morato ^[4] ; Santos, Antonio Carlos ^[5] ; Scrideli, Carlos Alberto ^[1] ; Oliveira, Ricardo Santos ^[6] ; Machado, Helio Rubens ^[6] ; Tone, Luiz Gonzaga ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pediat, Div Pediat Oncol, Fac Med Ribeirao Preto, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Internal Med, Fac Med Ribeirao Preto, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Div Radiol, Fac Med Ribeirao Preto, Dept Surg & Anat, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Div Neurosurg, Fac Med Ribeirao Preto, Dept Surg & Anat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROPATHOLOGY; v. 29, n. 5, p. 585-590, 2009.
• Citações Web of Science: 9

Resumo

Meningiomas are recognized as the most common late complication following radiotherapy. However, cytogenetic studies in childhood atypical radiation-induced meningioma are sporadic, mainly because this condition generally occurs after a long latent period. In the present study we show the results of conventional and molecular cytogenetics in a 14-year-old boy with a secondary atypical meningioma. Apart from numerical changes, we found complex aberrations with the participation of chromosomes 1, 6 and 12. The invariable presence of loss of 1p was demonstrated by fluorescent in situ hybridization (FISH) analysis with probes directed to telomeric regions and by comparative genome hybridization (CGH). Previous cytogenetic studies on adult spontaneous and radiation-associated meningiomas showed loss of chromosome 22 as the most frequent change, followed by loss of the short arm of chromosome 1. To the best of our knowledge this is the first report of highly complex chromosome aberrations in the pediatric setting of meningioma. (AU)

• Processo FAPESP: 07/54236-4 - Analise do perfil genomico em neoplasias da infancia atraves da hibridizacao genomica comparativa.
• Beneficiário: Luiz Gonzaga Tone
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/04827-3 - Análise de aneuploidias por hibridação genômica comparativa (CGH) em pacientes pediátricos portadores de leucemia linfóide aguda
• Beneficiário: María Sol Brassesco Annichini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado