Immunopathogenic competences of Leishmania (V.) braziliensis and L. (L.) amazonensis in American cutaneous leishmaniasis

Autor(es)

Silveira, F. T. ^{[1, 2]} ; Lainson, R. ^[2] ; Gomes, C. M. De Castro ^[3] ; Laurenti, M. D. ^[3] ; Corbett, C. E. P. ^[3]

Afiliação do(s) autor(es)

^[1] Fed Univ Para, Inst Trop Med, BR-66059 Belem, Para - Brazil

^[2] Minist Hlth, Evandro Chagas Inst, Dept Parasitol, BR-66090000 Belem, Para - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PARASITE IMMUNOLOGY; v. 31, n. 8, p. 423-431, 2009.
• Citações Web of Science: 106

Resumo

P>The immunopathogenic competences of Leishmania (V.) braziliensis and L. (L.) amazonensis were reviewed in the light of more recent features found in the clinical and immunopathological spectrum of American cutaneous leishmaniasis. It was shown a dichotomy in the interaction between these Leishmania species and human T-cell immune response; while L. (V.) braziliensis shows a clear tendency to lead infection from the localized cutaneous leishmaniasis (LCL), a moderate T-cell hypersensitivity form at the centre of the spectrum, toward to the mucocutaneous leishmaniasis (MCL) at the T-cell hypersensitivity pole and with a prominent Th1-type immune response, L. (L.) amazonensis shows an opposite tendency, leading infection to the anergic diffuse cutaneous leishmaniasis (ADCL) at the T-cell hyposensitivity pole and with a marked Th2-type immune response. Between the central LCL and the two polar MCL and ADCL, the infection can present an intermediary form known as borderline disseminated cutaneous leishmaniasis, characterized by an incomplete inhibition of T-cell hypersensitivity but with a evident supremacy of Th1 over Th2 immune response (Th1 >= Th2). These are probably the main immunopathogenic competences of L. (V.) braziliensis and L. (L.) amazonensis regarding the immune response dichotomy that modulates human infection outcome by these Leishmania parasites. (AU)

• Processo FAPESP: 06/56319-1 - Leishmanioses no Brasil: aspectos clínicos e imunopatogenéticos da doença humana e experimental
• Beneficiário: Carlos Eduardo Pereira Corbett
• Modalidade de apoio: Auxílio à Pesquisa - Temático