Conductometric Determination of N-acetylcysteine in Pharmaceutical Formulations Using Copper(II) Sulphate as Titrant

Autor(es)

Janegitz, Bruno Campos ^[1] ; Suarez, Willian Toito ^[1] ; Fatibello-Filho, Orlando ^[1] ; Marcolino-Junior, Luiz Humberto ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Chem, BR-13560 Sao Carlos, PR - Brazil

^[2] Univ Fed Parana, Dept Chem, BR-80060000 Curitiba, PR - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Analytical Letters; v. 41, n. 18, p. 3264-3271, 2008.
• Citações Web of Science: 18

Resumo

A simple, precise, rapid, and low-cost conductometric method for N-acetylcysteine determination in pharmaceutical formulations is proposed. N-acetylcysteine present in pharmaceuticals containing known quantities of the drug was conductometrically titrated in aqueous solution with copper(II) sulphate using a conductometric cell coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets such as sodium monophosphate, saccharine, sodium benzoate, sucrose, and fructose. Recoveries of N-acetylcysteine from various tablet dosage formulations ranging from 98.3 to 102.0% were obtained. (AU)

• Processo FAPESP: 06/05146-0 - Desenvolvimento de sensores utilizando nanotubos de carbono ou pó de grafite modificados com quitosana reticulada para a determinação de íons metálicos de alta toxicidade em águas residuárias
• Beneficiário: Bruno Campos Janegitz
• Modalidade de apoio: Bolsas no Brasil - Mestrado