Conductometric Determination of N-acetylcysteine in Pharmaceutical Formulations Using Copper(II) Sulphate as Titrant

Author(s)

Janegitz, Bruno Campos ^[1] ; Suarez, Willian Toito ^[1] ; Fatibello-Filho, Orlando ^[1] ; Marcolino-Junior, Luiz Humberto ^[2]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Chem, BR-13560 Sao Carlos, PR - Brazil

^[2] Univ Fed Parana, Dept Chem, BR-80060000 Curitiba, PR - Brazil

• Document type: Journal article
• Source: Analytical Letters; v. 41, n. 18, p. 3264-3271, 2008.
• Web of Science Citations: 18

Abstract

A simple, precise, rapid, and low-cost conductometric method for N-acetylcysteine determination in pharmaceutical formulations is proposed. N-acetylcysteine present in pharmaceuticals containing known quantities of the drug was conductometrically titrated in aqueous solution with copper(II) sulphate using a conductometric cell coupled to an autotitrator. No interferences were observed in the presence of common components of the tablets such as sodium monophosphate, saccharine, sodium benzoate, sucrose, and fructose. Recoveries of N-acetylcysteine from various tablet dosage formulations ranging from 98.3 to 102.0% were obtained. (AU)

• FAPESP's process: 06/05146-0 - Development of sensors using carbon nanotubes or graphite powder modified with crosslinked chitosan to determine high toxicity metal ions in wastewater
• Grantee: Bruno Campos Janegitz
• Support Opportunities: Scholarships in Brazil - Master