|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||September 01, 2011|
|Effective date (End):||August 31, 2012|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Analytical Chemistry|
|Principal Investigator:||Orlando Fatibello Filho|
|Grantee:||Deborah Asbahr de Lima|
|Home Institution:||Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil|
In this work, voltammetric techniques for the determination of methotrexate (an antimetabolite) in pharmaceutical formulations using a bismuth film electrode as working electrode will be employed. All system´s variables will be optimized in order to obtain the best results in terms of analytical sensitivity, reproducibility, selectivity, precision and accuracy. Addition and recovery, repeatability and potential interfering species studies will be carried out and, the method will be applied to determine methotrexate in pharmaceutical formulations. The results will be compared with those obtained using the standard method of British Pharmacopoeia, Brazilian or some method proposed in the literature.