Voltammetric determination of methotrexate using a bismuth film electrode

• Grant number: 11/13368-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2011
• End date: August 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Orlando Fatibello Filho
• Grantee: Deborah Asbahr de Lima
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

In this work, voltammetric techniques for the determination of methotrexate (an antimetabolite) in pharmaceutical formulations using a bismuth film electrode as a working electrode will be employed. All system variables will be optimized in order to obtain the best results in terms of analytical sensitivity, reproducibility, selectivity, precision, and accuracy. Addition and recovery, repeatability, and potential interfering species studies will be carried out and, the method will be applied to determine methotrexate in pharmaceutical formulations. The results will be compared with those obtained using the standard method of British Pharmacopoeia, Brazilian, or some method proposed in the literature.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ASBAHR, DEBORAH; FIGUEIREDO-FILHO, LUIZ CARLOS S.; VICENTINI, FERNANDO CAMPANHA; OLIVEIRA, GEISER GABRIEL; FATIBELLO-FILHO, ORLANDO; BANKS, CRAIG E.. Differential pulse adsorptive stripping voltammetric determination of nanomolar levels of methotrexate utilizing bismuth film modified electrodes. SENSORS AND ACTUATORS B-CHEMICAL, v. 188, p. 334-339, NOV 2013. (10/20754-1, 11/13368-0)