| Texto completo | |
| Autor(es): |
Vidotto, J. P.
[1]
;
Pereira, L. A. A.
[1]
;
Braga, A. L. F.
[1]
;
Silva, C. A.
[2, 1, 3]
;
Sallum, A. M.
[1, 3]
;
Campos, L. M.
[1, 3]
;
Martins, L. C.
[1]
;
Farhat, S. C. L.
[1, 4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Med, Lab Expt Air Pollut, Environm Epidemiol Study Grp, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Div Rheumatol, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Childrens Inst, Paediat Rheumatol Unit, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Dept Paediat, Hosp Clin, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Lupus; v. 21, n. 5, p. 526-533, APR 2012. |
| Citações Web of Science: | 19 |
| Resumo | |
Objective: To investigate the lag structure effects from exposure to atmospheric pollution in acute outbursts in hospital admissions of paediatric rheumatic diseases (PRDs). Methods: Morbidity data were obtained from the Brazilian Hospital Information System in seven consecutive years, including admissions due to seven PRDs (juvenile idiopathic arthritis, systemic lupus erythematosus, dermatomyositis, Henoch-Schonlein purpura, polyarteritis nodosa, systemic sclerosis and ankylosing spondylitis). Cases with secondary diagnosis of respiratory diseases were excluded. Daily concentrations of inhaled particulate matter (PM10), sulphur dioxide (SO2) nitrogen dioxide (NO2), ozone (O-3) and carbon monoxide (CO) were evaluated. Generalized linear Poisson regression models controlling for short-term trend, seasonality, holidays, temperature and humidity were used. Lag structures and magnitude of air pollutants' effects were adopted to estimate restricted polynomial distributed lag models. Results: The total number of admissions due to acute outbursts PRD was 1,821. The SO2 interquartile range (7.79 mu g/m(3)) was associated with an increase of 1.98% (confidence interval 0.25-3.69) in the number of hospital admissions due to outcome studied after 14 days of exposure. This effect was maintained until day 17. Of note, the other pollutants, with the exception of O-3, showed an increase in the number of hospital admissions from the second week. Conclusion: This study is the first to demonstrate a delayed association between SO2 and PRD outburst, suggesting that oxidative stress reaction could trigger the inflammation of these diseases. Lupus (2012) 21, 526-533. (AU) | |
| Processo FAPESP: | 08/05192-7 - Avaliação da influência da poluição atmosférica sobre internações de crianças e adolescentes portadores de doenças do tecido conectivo na cidade de são paulo |
| Beneficiário: | Juliana Peres Vidotto |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |