Levels and patterns of expression of hypoxia-inducible factor-1a, vascular endothelial growth factor, glucose transporter-1 and CD105 in adenoid cystic carcinomas with high-grade transformation

Autor(es):Mostrar menos -

Costa, Ana F. ^[1] ; Tasso, Marcelo G. ^[1] ; Mariano, Fernanda V. ^[2] ; Soares, Andresa B. ^[3] ; Chone, Carlos T. ^[4] ; Crespo, Agricio N. ^[4] ; Fresno, Manuel F. ^[5] ; Llorente, Jose L. ^[6] ; Suarez, Carlos ^[6] ; de Araujo, Vera C. ^[3] ; Hermsen, Mario ^[6] ; Altemani, Albina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Dept Pathol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Dept Oral Pathol, Piracicaba - Brazil

^[3] Sao Leopoldo Mand Inst & Res Ctr, Dept Oral Pathol, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Dept Otolaryngol Head & Neck Surg, Campinas, SP - Brazil

^[5] Hosp Univ Cent Asturias, Dept Pathol, Oviedo - Spain

^[6] Hosp Univ Cent Asturias, IUOPA, Dept Otolaryngol, Oviedo - Spain

• Tipo de documento: Artigo Científico
• Fonte: Histopathology; v. 60, n. 5, p. 816-825, APR 2012.
• Citações Web of Science: 15

Resumo

Aims: To compare the expression of proteins regulated by hypoxia between adenoid cystic carcinoma (ACC) with and without high-grade transformation (HGT). Methods and results: In eight ACC-HGT and 18 ACC without HGT, expression of hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor (VEGF), glucose transporter-1 (GLUT-1) and microvascular density (MVD) by CD105 (a hypoxia-inducible protein expressed in angiogenic endothelial cells) was determined. Expression levels of HIF-1a and VEGF as well as CD105-MVD did not differ significantly between: (i) transformed and conventional areas (TA and CA, respectively) of ACC-HGT, (ii) CA and ordinary ACC. HIF-1a was detected in 100% of cases and presented a diffuse expression pattern. No significant association was found between levels of HIF-1a expression and tumour size, metastasis and recurrence. GLUT-1 showed a prostromal expression pattern and was observed exclusively in TA (three of six cases) and in only three of 14 ACC. Conclusions: Both the absence of significant alterations in levels of expression of HIF-1a, VEGF and CD105 and the patterns of expression of HIF-1a and GLUT-1 suggest that hypoxia may not play a key role in the process of high-grade transformation of ACC. Although HIF-1a expression is a common finding in ACC, it cannot be used as a marker of tumour aggressiveness. (AU)

• Processo FAPESP: 10/51571-0 - Identificação das alterações genéticas e epigenéticas no carcinoma adenóide cístico com transformação para alto grau
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/54377-2 - Identificação das alterações genéticas e epigenéticas no carcinoma adenoide cístico com transformação para alto grau
• Beneficiário: Ana Flávia de Mattos Costa
• Modalidade de apoio: Bolsas no Brasil - Doutorado