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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Levels and patterns of expression of hypoxia-inducible factor-1a, vascular endothelial growth factor, glucose transporter-1 and CD105 in adenoid cystic carcinomas with high-grade transformation

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Author(s):
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Costa, Ana F. [1] ; Tasso, Marcelo G. [1] ; Mariano, Fernanda V. [2] ; Soares, Andresa B. [3] ; Chone, Carlos T. [4] ; Crespo, Agricio N. [4] ; Fresno, Manuel F. [5] ; Llorente, Jose L. [6] ; Suarez, Carlos [6] ; de Araujo, Vera C. [3] ; Hermsen, Mario [6] ; Altemani, Albina [1]
Total Authors: 12
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Dept Pathol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Dept Oral Pathol, Piracicaba - Brazil
[3] Sao Leopoldo Mand Inst & Res Ctr, Dept Oral Pathol, Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Dept Otolaryngol Head & Neck Surg, Campinas, SP - Brazil
[5] Hosp Univ Cent Asturias, Dept Pathol, Oviedo - Spain
[6] Hosp Univ Cent Asturias, IUOPA, Dept Otolaryngol, Oviedo - Spain
Total Affiliations: 6
Document type: Journal article
Source: Histopathology; v. 60, n. 5, p. 816-825, APR 2012.
Web of Science Citations: 15
Abstract

Aims: To compare the expression of proteins regulated by hypoxia between adenoid cystic carcinoma (ACC) with and without high-grade transformation (HGT). Methods and results: In eight ACC-HGT and 18 ACC without HGT, expression of hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor (VEGF), glucose transporter-1 (GLUT-1) and microvascular density (MVD) by CD105 (a hypoxia-inducible protein expressed in angiogenic endothelial cells) was determined. Expression levels of HIF-1a and VEGF as well as CD105-MVD did not differ significantly between: (i) transformed and conventional areas (TA and CA, respectively) of ACC-HGT, (ii) CA and ordinary ACC. HIF-1a was detected in 100% of cases and presented a diffuse expression pattern. No significant association was found between levels of HIF-1a expression and tumour size, metastasis and recurrence. GLUT-1 showed a prostromal expression pattern and was observed exclusively in TA (three of six cases) and in only three of 14 ACC. Conclusions: Both the absence of significant alterations in levels of expression of HIF-1a, VEGF and CD105 and the patterns of expression of HIF-1a and GLUT-1 suggest that hypoxia may not play a key role in the process of high-grade transformation of ACC. Although HIF-1a expression is a common finding in ACC, it cannot be used as a marker of tumour aggressiveness. (AU)

FAPESP's process: 10/51571-0 - Identification of genetic and epigenetic alterations in adenoid cystic carcinoma with high-grade transformation
Grantee:Albina Messias de Almeida Milani Altemani
Support Opportunities: Regular Research Grants
FAPESP's process: 09/54377-2 - Identification of genetic and epigenetic alterations in adenoid cystic carcinoma with high-grade transformation
Grantee:Ana Flávia de Mattos Costa
Support Opportunities: Scholarships in Brazil - Doctorate