Effect of Genetic Variants Related to Lipid Metabolism as Risk Factors for Cholelithiasis After Bariatric Surgery in Brazilian Population

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Pinheiro-Junior, Sidney ^[1] ; Pinhel, Marcela A. S. ^[1] ; Nakazone, Marcelo A. ^[1] ; Pinheiro, Anielli ^[1] ; Amorim, Gisele F. S. ^[1] ; Florim, Greiciane M. S. ^[1] ; Mazeti, Camila M. ^[1] ; Gregorio, Michele L. ^[1] ; Moschetta, Marina G. ^[1] ; Brito, Gilberto B. ^[2] ; Brienze, Sergio L. A. ^[2] ; Nonino, Carla B. ^[3] ; Brandao, Antonio C. ^[1] ; Souza, Doroteia R. S. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Jose do Rio Preto Med Sch, Dept Mol Biol, Ctr Biochem & Mol Biol Res, BR-15090000 Sao Paulo - Brazil

^[2] Sao Jose do Rio Preto Med Sch, Dept Surg Specialties, BR-15090000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Nutr, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: OBESITY SURGERY; v. 22, n. 4, p. 623-633, APR 2012.
• Citações Web of Science: 6

Resumo

The manifestation of cholelithiasis after bariatric surgery may depend on genetic factors related to lipid metabolism, including apolipoprotein E (APOE) and cholesteryl ester transfer protein (CETP) gene polymorphisms. We investigated the association between APOE HhaI and CETP TaqIB polymorphisms {[}PCR-RFLP] and occurrence of cholelithiasis over up to 8 months of follow-up after gastroplasty to Roux-en-Y gastric bypass in 220 patients distributed in Group 1 (G1) 114 with cholelithiasis postoperatively and Group 2 (G2) 106 without cholelithiasis, including biochemical and anthropometric profiles analyses. In our series, the allelic and genotypic distributions of CETP TaqIB and APOE HhaI polymorphisms were similar in both groups (P > 0.05). The subgroup analysis evidenced that 54% of the patients from G1, APOE{*}4 allele carriers compared with APOE{*}3/3 carriers, presented altered low-density lipoprotein cholesterol (LDL cholesterol) serum levels (P = 0.022) before bariatric surgery. The B1 allele for CETP was associated to more quickly elevation of HDL cholesterol levels just in individuals without cholelitiasis (P < 0.0001). The multivariate logistic regression analysis demonstrates correlation between APOE{*}4 allele, higher total cholesterol (TC) serum levels and prediposition to cholelitiasis in preoperative period. However, the presence of postoperative cholelithiasis was not associated with altered lipid profile. The CETP TaqIB and APOE HhaI polymorphisms do not seem to have association with gallstones in the late postoperative bariatric surgery, considering that these genetic variants do not differ subgroups of patients who are eligible to routine prophylactic cholecystectomy, at least in Brazilian population. (AU)

• Processo FAPESP: 08/54059-8 - Apolipoproteina e como fator de risco para colelitiase apos cirurgia bariatrica na obesidade morbida
• Beneficiário: Dorotéia Rossi Silva Souza
• Modalidade de apoio: Auxílio à Pesquisa - Regular