Morphological study of accessory gland of Bothrops jararaca and its secretory cycle

Autor(es)

Sakai, Fernancla ^[1] ; Carneiro, Sylvia M. ^[2] ; Yamanouye, Norma ^[1]

Afiliação do(s) autor(es)

^[1] Inst Butantan, Farmacol Lab, BR-05503900 Sao Paulo - Brazil

^[2] Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Toxicon; v. 59, n. 3, p. 393-401, MAR 1 2012.
• Citações Web of Science: 8

Resumo

The venom gland apparatus of Bothrops jararaca is composed of four distinct parts: main venom gland, primary duct, accessory gland and secondary duct. Despite the numerous studies concerning morphology and venom production and secretion in the main venom gland, there are few studies about the accessory gland and its secretion. We characterized the accessory gland of B. jararaca snake and determined the secretion cycle by morphological analysis using light and transmission electron microscopy. Our data showed that the accessory gland of B. jararaca has a simple secretory epithelium with at least six types of cells in the anterior region: two types of secretory cells, mitochondria-rich cells without secretory vesicles, horizontal cells, dark cells and basal cells, and in the posterior region a simple epithelium with two types of cells: seromucous cells and horizontal cells. Furthermore, the mucous secretory cells of the accessory gland show a delayed and massive exocytosis that occurs four days after the extraction of venom. Morphological analysis at different steps after venom extraction showed that the accessory gland has a long cycle of production and secretion, which is not synchronous with the main venom gland secretory cycle. (c) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/51522-9 - Glândula acessória e ducto primário de serpente Bothrops jararaca macho e fêmea durante o ciclo de produção de veneno: um estudo morfológico
• Beneficiário: Fernanda Sakai
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/50083-9 - Mecanismos celulares envolvidos na produção e secreção de veneno: sistema nervoso simpático na glândula de veneno e na glândula acessória da serpente Bothrops jararaca
• Beneficiário: Norma Yamanouye
• Modalidade de apoio: Auxílio à Pesquisa - Regular