Low-dose Enalapril Reduces Angiotensin II and Attenuates Diabetic-induced Cardiac and Autonomic Dysfunctions

Autor(es):Mostrar menos -

Malfitano, Christiane ^{[1, 2, 3]} ; De Angelis, Katia ^{[1, 4]} ; Fernandes, Tiago ^[5] ; Wichi, Rogerio Brandao ^[1] ; Rosa, Kaleizu ^[1] ; Pazzine, Mariana ^[1] ; Mostarda, Cristiano ^[1] ; Ronchi, Fernanda Aparecida ^[2] ; de Oliveira, Edilamar Menezes ^[5] ; Casarini, Dulce Elena ^[2] ; Irigoyen, Maria-Claudia ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, BR-05403000 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Nephrol, Sao Paulo - Brazil

^[3] Univ Cardiol Fdn, PROCAD Cardiol Inst, Porto Alegre, RS - Brazil

^[4] Univ Nove Julho, Dept Rehabil Sci, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Phys Educ & Sports, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cardiovascular Pharmacology; v. 59, n. 1, p. 58-65, JAN 2012.
• Citações Web of Science: 9

Resumo

Activation of renin-angiotensin system has been linked to cardiovascular and autonomic dysfunctions in diabetes. Experiments were performed to investigate the effects of angiotensin-converting enzyme inhibitor (ACEI), enalapril, on cardiac and autonomic functions in diabetic rats. Diabetes was induced by streptozotocin (50 mg/kg), and rats were treated with enalapril (1 mg.kg(-1).d(-1)). After 30 days, evaluations were performed in control, diabetic, and enalapril-treated groups. Cardiac function was evaluated by echocardiography and through cannulation of the left ventricle (at baseline and in response to volume overload). Heart rate and systolic blood pressure variabilities were evaluated in the time and frequency domains. Streptozotocin rats had left ventricular systolic and diastolic dysfunctions, expressed by reduced ejection fraction and increased isovolumic relaxation time. The ACEI prevented these changes, improved diastolic cardiac responses to volume overload and total power of heart rate variability, reduced the ACE1 activity and protein expression and cardiac angiotensin (Ang) II levels, and increased angiotensin-converting enzyme 2 activity, despite unchanged blood pressure. Correlations were obtained between Ang II content with systolic and diastolic functions and heart rate variability. These findings provide evidence that the low-dose ACEI prevents autonomic and cardiac dysfunctions induced by diabetes without changing blood pressure and associated with reduced cardiac Ang II and increased angiotensin-converting enzyme 2 activity. (AU)

• Processo FAPESP: 04/04283-8 - Papel do sistema renina angiotensina nas alterações cardiovasculares do diabetes experimental: avaliações in vivo e in vitro
• Beneficiário: Christiane Malfitano
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores