Alzheimer's disease qEEG Spectral analysis versus coherence. Which is the best measurement?

Autor(es):Mostrar menos -

Anghinah, Renato ^[1] ; Medeiros Kanda, Paulo Afonso ^[1] ; Lopes, Helder Frederico ^[1] ; Hindi Basile, Luis Fernando ^{[1, 2]} ; Machado, Sergio ^[3] ; Ribeiro, Pedro. ^[3] ; Velasques, Bruna ^[3] ; Sameshima, Koichi ^[4] ; Takahashi, Daniel Yasumasa ^[4] ; Pinto, Lecio Figueira ^[1] ; Caramelli, Paulo ^[5] ; Nitrini, Ricardo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo - Brazil

^[2] Methodist Univ Sao Paulo UMESP, Psychophysiol Lab, Sao Paulo - Brazil

^[3] Fed Univ Rio de Janeiro IPUB UFRJ, Inst Psychiat, Rio De Janeiro - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo - Brazil

^[5] Univ Fed Minas Gerais, Fac Med, Dept Internal Med, Cognit & Behabioral Neurol Unit, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Arquivos de Neuro-Psiquiatria; v. 69, n. 6, p. 871-874, DEC 2011.
• Citações Web of Science: 9

Resumo

There is evidence in electroencephalography that alpha, theta and delta band oscillations reflect cognitive and memory performances and that quantitative techniques can improve the electroencephalogram (EEG) sensitivity. This paper presents the results of comparative analysis of qEEG variables as reliable markers for Alzheimer's disease (AD). We compared the sensitivity and specificity between spectral analysis (spectA) and coherence (Coh) within the same group of AD patients. SpectA and Coh were calculated from EEGs of 40 patients with mild to moderate AD and 40 healthy elderly controls. The peak of spectA was smaller in the AD group than in controls. AD group showed predominance of slow spectA in theta and delta bands and a significant reduction of inter-hemispheric Coh for occipital alpha 2 and beta 1 and for frontal delta sub-band. ROC curve supported that alpha band spectA was more sensitive than coherence to differentiate controls from AD. (AU)

• Processo FAPESP: 03/02297-9 - Topografia cortical dos potenciais lentos, ritmos induzidos e sincronizações associados à atenção
• Beneficiário: Luis Fernando Hindi Basile
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 02/13633-7 - Metabolismo de fosfolípides em doenças neuropsiquiátricas
• Beneficiário: Wagner Farid Gattaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático